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Online Sinequan (Doxepin)

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On this page: Overview FAQ Gov/NIH

Overview

Doxepin, branded Sinequan, is a tricyclic antidepressant with potent antihistamine and sedative properties.

Uses

Indicated for depression, anxiety, and insomnia. Low-dose formulations (3–6 mg) are approved specifically for sleep maintenance insomnia.

Dosage & Administration

Depression/anxiety: 75–150 mg/day, up to 300 mg if needed. For insomnia: 3–6 mg nightly.

Side Effects & Warnings

Drowsiness, weight gain, and dry mouth are common. Serious: QT prolongation, urinary retention, and confusion in elderly. Avoid MAOIs and alcohol.

Patient Considerations

Take at bedtime. Adjust dose gradually.

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FAQ

Is Sinequan mainly a sleep aid?

At low doses, yes.

Does it cause dependence?

No physical dependence, but tolerance may develop.

Can Sinequan cause weight gain?

Yes, due to antihistaminic effect.

Government / NIH sources

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