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Online Motrin (Ibuprofen)

Pain & Inflammation • Educational only; not medical advice. Prescriptions at clinician discretion.

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On this page: Overview FAQ Gov/NIH

Overview

Ibuprofen, sold as Motrin and other brands, is a non-steroidal anti-inflammatory drug (NSAID) that inhibits prostaglandin synthesis by blocking cyclooxygenase (COX-1 and COX-2) enzymes. Developed in the 1960s, it remains one of the world’s most used analgesics and antipyretics.

Uses

Relieves mild-to-moderate pain, inflammation, and fever associated with headache, toothache, arthritis, dysmenorrhea, and musculoskeletal injuries.

Dosage & Administration

Adults: 200–400 mg every 4–6 hours as needed (max 1200 mg/day OTC, 2400 mg/day prescription). Take with food or milk to reduce stomach upset.

Side Effects & Warnings

Common: stomach discomfort, heartburn, and nausea. Serious: ulcers, gastrointestinal bleeding, renal impairment, and cardiovascular events with long-term use. Contraindicated in active ulcer disease, severe heart failure, or hypersensitivity to NSAIDs.

Patient Considerations

Use the lowest effective dose for the shortest time. Avoid combining with alcohol or other NSAIDs.

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FAQ

Can I take Motrin on an empty stomach?

Preferably with food.

Is Motrin safe in pregnancy?

Avoid in the third trimester.

Can I mix Motrin and acetaminophen?

Yes, alternating may enhance pain relief under guidance.

Government / NIH sources

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