Online Phenergan (Promethazine)
Respiratory & Allergy • Educational only; not medical advice. Prescriptions at clinician discretion.
Overview
Promethazine, marketed as Phenergan, is a first-generation antihistamine of the phenothiazine class with strong sedative and antiemetic properties. It blocks H₁-histamine receptors and also exhibits anticholinergic and dopaminergic antagonism.
Uses
Indicated for allergy symptoms, motion sickness, nausea and vomiting, sedation, and adjunctive treatment of postoperative pain. Also used as a nighttime sleep aid.Dosage & Administration
Oral dose: 12.5–25 mg every 4–6 hours as needed; for motion sickness, 25 mg before travel. Parenteral and suppository forms are available. Children under two years should not receive it due to respiratory-depression risk.Side Effects & Warnings
Drowsiness, dry mouth, blurred vision, and constipation are common. Serious reactions: respiratory depression, neuroleptic-malignant-like syndrome, and tissue necrosis with extravasation (IV). Contraindicated with other CNS depressants or MAOIs.Patient Considerations
Avoid driving, alcohol, or sedatives. Use only short-term for sleep or nausea control.Ready for next steps?
FAQ
Is Phenergan safe for kids?
Not for children under two; older children require careful dosing.
Can I use Phenergan for anxiety?
It is not approved for anxiety; sedatives with fewer risks are preferred.
Does it help motion sickness?
Yes, it is effective when taken 30–60 minutes before travel.
Government / NIH sources
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